The major circulating metabolite is the methylcatechol glucuronide. The improvement in 6-MWD was apparent at 8 weeks of treatment and then maintained at week 12 and week Systemic drug exposures, as measured by AUC of unbound tadalafil, were approximately 5—fold for mice, and 7— and 14—fold for male and female rats, respectively, the exposures at the maximum recommended human dose MRHD of 40 mg. Exposure changes of drugs following co-administration with tadalafil are shown in Figure 3. The list does not include adverse events that are reported from clinical trials and that are listed elsewhere in this section. In a 12—month dog study, no disseminated arteritis was observed, but 2 dogs exhibited marked decreases in white blood cells neutrophils and moderate decreases in platelets with inflammatory signs at unbound tadalafil exposures of approximately 4— to 10—fold the human exposure at the MRHD of 40 mg.AdWalgreens Offers 1 Hour Delivery. Use Code WAG10 & Save 10% Instantly! Use Code WAG10 To Save 10% Instantly At Walgreens. Shop Online & Get Free Delivery!K+ visitors in the past month. Transfer your prescription for Adcirca (Brand for Tadalafil, Oral Tablet) on Amazon Pharmacy. FREE SHIPPING for Prime members. Tadalafil online 20mg | 10mg,5mg,40mg. If you experience any one of the complying with serious adverse effects of Tadalafil cease using this drug, Buy Tadalafil Generics Online.