No drug-drug interactions associated with dapoxetine have been reported Premature ejaculation can cause partners to feel less connected or hurt. By repeating as many times as needed, you can reach the point of entering your partner without ejaculating. How effective are SSRIs? Do you have premature ejaculation every time you have sex?When treating premature ejaculation, one of their side effects becomes useful: SSRIs also increase the time it takes until ejaculation occurs. Creams, gels or sprays that contain a . Dapoxetine, a new antidepressant, has been found to be safe and effective for the treatment of premature ejaculation, according to two major clinical trials. Dapoxetin is a . Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. [3] [4] [5] Dapoxetine works by .