The recommended starting dose is one 30 mg tablet, taken 1 to 3 hours before you anticipate having sex. FDB Multilex and those who are responsible for their construction, operation and maintenance do not know the particular circumstances, condition or medical history of particular patients or groups of patients and so cannot advise as to particular cases. Ques : Does Dapoxetine cure premature ejaculation? Importantly, clear evidence was found for improvements in interpersonal relationships, suggesting that both sexual partners benefitted from dapoxetine treatment. Pharmacotherapy of PE with off-label antidepressant selective serotonin reuptake inhibitors SSRIs is common, effective and safe.View dapoxetine information, including dose, uses, side-effects, renal impairment, contra-indications and drug action. Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. [3] [4] [5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. [6]. This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase I, II and III studies, independent postmarketing and pharmacovigilance efficacy and safety studies and drug-interaction studies. Dapoxetine is a potent SSRI which is administered on demand 1–3 h prior to planned sexual contact.