There were no clinically relevant mean changes in ECG or vital sign data. The column is coordinated by Robert A. In the other 21 phase I studies, four cases of syncope were reported. Adequately powered randomized, controlled trials were considered the strongest form of evidence but all other articles were also considered. Dapoxetine hydrochloride. Nausea was the most commonly reported adverse event, occurring with greater frequency in the dapoxetine mg group The most common adverse events were nausea, dizziness, diarrhea, insomnia, headache, and nervousness.The effects of PDE-5 inhibitors on the pharmacokinetics of dapoxetine were studied in a randomized, open-label, 3-period crossover study in healthy male subjects . rows · DrugBank Accession Number. DB Background. Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II . Type of medicine. A selective serotonin reuptake inhibitor. Used for. Premature ejaculation in adult men. Also called. Priligy®. Available as. Tablets. .