Find Us On. Animal and human sexual psychopharmacological studies have demonstrated that serotonin 5-hydroxy-tryptamine, 5-HT and 5-HT receptors are involved in ejaculation and confirm a role for selective serotonin reuptake inhibitors SSRIs in the treatment of PE [ Olivier et al. This search was then manually cross referenced for all papers. The full text of relevant articles was read and critiqued. It is advisable to consult a Psychiatrist before using this medicine.This review encompasses studies of dapoxetine pharmacokinetics, animal studies, human phase I, II and III studies, independent postmarketing and pharmacovigilance efficacy and safety studies and drug-interaction studies. Dapoxetine is a potent SSRI which is administered on demand 1–3 h prior to planned sexual contact. Dapoxetine is a short-acting selective serotonin re-uptake inhibitor. Indications and dose. Dapoxetine is a selective serotonin reuptake inhibitor specifically designed to treat PE. This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult men.