Conversely, patients already receiving an optimized dose of tadalafil should be started on the lowest dose of the alpha-blocker; increases in the alpha-blocker dose should be done in stepwise fashion. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Use caution when administering these drugs concomitantly. Recent heart or blood vessel problems. Indinavir: Major For the treatment of erectile dysfunction, do not exceed 10 mg of tadalafil within 72 hours of indinavir for the ‘as needed’ dose or 2. Before taking tadalafil, tell your doctor and pharmacist if you are allergic to tadalafil, any other medications, or any of the ingredients in tadalafil tablets.Healthcare providers may also prescribe tadalafil to manage two other health conditions involving insufficient blood flow: pulmonary arterial hypertension (PAH) . Tadalafil (Cialis). This medication is taken with or without food an hour before sex. It works for up to 36 hours. You can take it in a small dose daily or in a larger . Talk to your doctor about which dosing schedule is right for you. Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often .

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