Subsequently, the FDA approved both vardenafil [27] and tadalafil in After taking a single tablet, some of the active ingredient of Cialis remains in your body for more than 2 days. Symptoms may include sudden urges to urinate urgency , difficulty in starting urination hesitancy , a weak urine stream, and more frequent urination — especially at night. Patients who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may get side effects such as fainting or light-headedness. For further information contact your pharmacist or Eli Lilly and Company directly. · But on average, its effects start to lessen 2 to 3 hours after you take a dose. The typical dose for once-daily Cialis for ED is milligrams (mg) to 5 mg. When used as needed for ED, the usual. CIALIS for Use as Needed. Creatinine clearance 30 to 50 mL/min: A starting dose of 5 mg not more than once per day is recommended, and the maximum dose is 10 mg not more than once in every 48 hours. Creatinine clearance less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg not more than once in every 72 hours [see . 5 • Your healthcare provider may change your dose of CIALIS depending on how you respond to the medicine, and on your health condition. OR CIALIS for once daily use is a lower dose you take every day. • Do not take CIALIS more than one time each day. • Take one CIALIS tablet every day at about the same time of day. You may attempt sexual.